Men’s Formula Plus – Prevention Intervention

Prevention or Intervention at It’s Best

Shop Talk Notes

Men’s Formula Plus has been created as an integral part of a nutritional program to support prostate and urinary tract health. It is scientifically formulated with Calcium D-Glucarate, a patented ingredient for which Unicity™ holds exclusive distribution rights for this use within the multilevel marketing industry. Calcium D-Glucarate, a natural substance, nutritionally supports your body’s ability to eliminate toxins and other adverse substances.
Calcium D-Glucarate (CDG) is a natural substance produced by humans. Small amounts are also found in fruits and vegetables. Early humans were able to get enough calcium-d-glucarate from their own production since they ate relatively low amounts of toxins and lived in a clean environment. As toxin exposure has increased, humans need more calcium-d-glucarate to excrete the extra toxins.There is no *technical* deficiency of calcium-d-glucarate because it is not essential. However, humans produce small amounts, so it’s easy to develop low levels. Low levels of CDG are correlated with higher levels of beta-glucuronidase. Elevated beta-glucuronidase is a risk factor for cancer, especially hormone related cancers like breast, prostate, and colon cancer.
“Discovered by researchers at the M.D. Anderson Cancer Center in Texas, d-glucarates have been shown to decrease lung, skin, liver, breast and colon cancers by 60 percent or more (Walaszek, 1990). In addition, it has been found to have an inhibitor effect on cancers of the bladder and the prostate. In the breast, D-glucarate has been shown in more than 20 experimental animal and in vitro studies to significantly inhibit cancer. The primary mechanism of action of D-glucarate is through its ability to enhance detoxification of both chemical carcinogens from the environment and estrogenic tumor promoters produced by the body. Women who are at a higher risk for breast cancer have a lower detoxification capacity for carcinogens and estrogens. Likewise, D-glucarate has been found to effectively prevent the induction of prostate cancer in men.”
How the Body Gets Rid of Toxins
One of the ways the body gets rid of toxins is through a process called conjugation. During conjugation, toxins are packaged into water soluble compounds called glucuronides. Glucuronides are meant to pass from the liver, to the bile, then to the gut where they are excreted. However, high levels of an enzyme called beta-glucuronide can inhibit this process. This enzyme separates toxins from their conjugate bond and allows them to be reabsorbed. This allows toxins to keep circulating in the body where they make you fat, tired, and weak.Calcium-d-glucarate prevents beta-glucuronide from disturbing this process. It keeps the toxins bound inside a glucuronide which is then removed from the body. Toxins are most damaging in their free form, which is why you want them to be bound (conjugated) and released from the body. Calcium-d-glucarate inhibits beta-glucuronidase which allows toxins to be removed.
Calcium-d-Glucarate (CDG) is a natural substance produced by all humans. Small amounts are also found in fruits and vegetables. Early humans were able to get enough calcium-d-glucarate from their own production since they ate relatively low amounts of toxins and lived in a clean environment. As toxin exposure has increased, humans need more calcium-d-glucarate to excrete the extra toxins.There is no *technical* deficiency of calcium-d-glucarate because it is not essential. However, humans produce small amounts, so it’s easy to develop low levels. Low levels of CDG are correlated with higher levels of beta-glucuronidase. Elevated beta-glucuronidase is a risk factor for cancer, especially hormone related cancers like breast, prostate, and colon cancer.Here are four reasons calcium-d-glucarate is a seriously useful supplement.
Toxins cause mutations in DNA which leads to cancer. Along with retinoids, CDG reduces breast cancer in rats by 70 percent.Calcium-d-glucarate removes carcinogens and other tumor promoting agents.

“…increases detoxification of carcinogens and tumor promoters/progressors by inhibiting beta-glucuronidase and preventing hydrolysis of their glucuronides”

Calcium-d-glucarate increased toxin release and flushed out compounds that promote cancer. In rats with colon cancer, calcium-d-glucarate caused a sixty percent drop in tumor incidence. CDG also reduced the number of times cancer cells multiplied.One of the reasons smokers develop lung cancer is believed to be low levels of D-glucaric acid. Smokers have 29 percent less d-glucaric acid than healthy people. Another study in rats showed that calcium-d-glucarate decreased skin cancer formation by 30 percent.Calcium-d-glucarate is not guaranteed to prevent cancer, but everything helps.


When calcium-d-glucarate is taken orally, it’s metabolized into glucaric acid. This is the active form of calcium-d-glucarate and the one produced naturally by the body. Glucaric acid is not available as a supplement by itself which is why you have to buy calcium-d-glucarate. Another benefit of CDG over glucaric acid is a longer detox period. CDG detoxes the liver for five hours instead of one.
Removing toxins from the liver will increase liver function and promote a healthy metabolism. It will also allow your liver to flush out other toxins that could otherwise cause problems.
The body sends LDL molecules to supply various parts of the body with cholesterol and fats. Limited blood flow is one form of stress. Calcium-d-glucarate is metabolized into glucaric salts. Glucaric salts reduces beta-glucuronidase production by gut bacteria. Reducing beta-glucuronidase enhances enterohepatic (liver) circulation which reduces cholesterol synthesis. This causes lower cholesterol levels.In rats, CDG lowers total cholesterol by 12-15 percent, and LDL cholesterol by 30-35 percent. In humans, CDG lowers cholesterol by 12 percent, and LDL cholesterol by 28 percent. It can also lower triglycerides up to 43 percent.CDG is not arbitrarily playing with cholesterol numbers like statins. It decreases stress on the liver which lowers your need for cholesterol, especially LDL cholesterol.
Our livers and kidney efficiently process proteins and are able to remove harmful byproducts like ammonia. However, humans can only handle so many toxins. The human body is involved fending off xenoestrogens, air pollutants, chronic infections, and mycotoxins. This leaves very little room for dealing with the metabolites of protein. Our modern world is so polluted, that humans don’t always have the necessary means to fend off natural byproducts of a healthy metabolism. If you’re consuming a high protein diet (25-35 percent), you should consider supplementing with calcium-d-glucarate.


High estrogen is also a problem for men. Whether your a man or woman, calcium-d-glucarate will help maintain proper hormone balance. High levels of beta-glucuronide increase the number of estrogen receptors. This means estrogen that would have been excreted is now able to bind to more receptors. This can cause increased tissue growth, cancer, and even man boobs.
Calcium d-glucarate has been studied extensively at the MD Anderson Cancer Clinic in Houston Texas and has approximately 17 papers published on its compounds and mechanisms. It has been shown to aid in the free radicals associated with Colon, Liver,
Bladder, Skin, Breast, Prostrate and Lung cancers; by attaching to the free radical cell that causes cancer, rendering it water soluble, thereby allowing the body to wash these cells from the body.
This formula contains 400 mg of Calcium d-glucarate,which is is equivalent to the phytonutrient activity found in approximately 65.6 LBs of fresh fruits and vegetables. However when this substance is present in therapeutic doses which start at 12-1600 mg per day it has been shown to stop the proliferation of specific cancers in the body.…
Saw Palmetto
Saw Palmetto extract is an extract of the fruit of Serenoa repens. It is rich in fatty acids and phytosterols. It has been used in traditional, eclectic, and alternative medicine to treat a variety of conditions, in particular benign prostatic hyperplasia (BPH). Reviews of clinical trials, including those conducted by the National Center for Complementary and Alternative Medicine, found the extract to be no more effective than placebo for BPH.
Saw Palmetto is used for treating certain types of prostate infections. It is also sometimes used, in combination with other herbs, to treat prostate cancer. It is also used to increase urine flow (as a diuretic), to promote relaxation (as a sedative), and to enhance sexual drive (as an aphrodisiac).However, its most pronounced effects appear to be those exerted upon the urino-genital tracts of both male and female, and upon all the organs concerned in reproduction. It is said to enlarge wasted organs, such as the testicles, while the paradoxical claim is also made that it reduces hypertrophy of the prostate. Possibly this may be explained by claiming that it tends toward the production of a normal condition, reducing parts when unhealthily enlarged, and increasing them when atrophied.

Orange Peel Extract

Orange peels are rich in flavonoids, like hesperidin and polymethoxyflavones (PMFs), and other phytochemicals, which contribute many of their health benefits. Orange peel also contains considerable amounts of calcium, copper, magnesium, vitamin A, folate and other B vitamins and dietary fiber.
The flavonoids in orange peel have the potential to inhibit the RLIP76 protein, which is linked to cancer and obesity.
Research is in the early stages, but if an orange peel extract could inhibit or reduce expression of RLIP76, it would have significant implications for chronic disease.”When you get rid of this [RLIP76] gene in a mouse, it would appear that the mouse can’t get obese, it can’t get diabetes, it can’t get high cholesterol and it can’t get cancer,” said Sanjay Awasthi, M.D., professor in the Division of Molecular Diabetes Research at City of Hope hospital.6Flavonoids in orange and other citrus peels exert a number of additional anti-cancer effects as well. According to research published in the journal BioMed Research International:7
  • “Due to their broad range of pharmacological properties, citrus flavonoids have gained increased attention. Accumulative in vitro and in vivo studies indicate protective effects of polymethoxyflavones (PMFs) against the occurrence of cancer.
  • PMFs inhibit carcinogenesis by mechanisms like blocking the metastasis cascade, inhibition of cancer cell mobility in circulatory systems, proapoptosis, and antiangiogenesis.…
  • Taken all together, a considerable number of well-established lines of evidence have confirmed that flavonoids in citrus peel exhibit a remarkable spectrum of efficacious biological activities, particularly in antitumorigenesis.
  • Compounds in orange peels and other citrus peel may prevent histamine release (histamines are the chemicals that cause allergic reactions), making them a potentially anti-allergic food.
  • The peels may also help to cleanse your lungs, helping you to expel phlegm, and the high levels of vitamin C are beneficial for your immune system, which may help you fight off respiratory illnesses like colds and flu.
  • In addition, citrus peel extract helps suppress inflammation similar to the anti-inflammatory drug indomethacin.
  • The peel may offer a range of additional health benefits as well, including: Improve digestion and speed metabolism, according to the principles of Ayurveda.

Pumpkin Seed


Pumpkin Seeds have long been valued as an important natural food for men’s health. This is in part because of their high zinc content, which is important for prostate health (where it is found in the highest concentrations in the body), and also because pumpkin seed extracts and oils may play a role in treating benign prostatic hyperplasia (BPH, or enlarged prostate). Research suggests that both pumpkin seed oil and pumpkin seeds may be particularly beneficial in supporting prostate health.
  • Research shows that water-soluble pumpkin seed extract is able to strengthen the pelvic floor muscles of the bladder by:
  • Allowing more testosterone to become available to the pelvic muscles
  • Binding to the pelvic-floor androgen receptors, further strengthening the pelvic muscles.
  • Helping to allow the bladder to relax (by increasing nitric oxide)
  • Helping to prevent and reverse prostate enlargement in men
Pumpkin is used for treating bladder irritation, kidney infections, intestinal worms, and trouble urinating due to benign prostatic hyperplasia (BPH)

Beta Sitosterol

Beta-sitosterol is a substance found in plants. Chemists call it a “plant sterol ester.” It is found in fruits, vegetables, nuts, and seeds. It is used to make medicine. It can also bind to the prostate to help reduce swelling (inflammation).
Dicalcium Phosphate
Dicalcium Phosphate is the chemical formula CaHPO4; it’s a combination of positively charged particles of calcium, and negatively charged particles of hydrogen phosphate, which is interchangeable with phosphate in the body. As such, it’s a source of both the mineral calcium and of phosphate, which you use for a variety of purposes, explains the Linus Pauling Institute. These include producing bone matrix and synthesizing DNA, which is genetic material. This is used in this formulation to create a slow release action of the key ingrediants.
Croscarmellose sodium is an internally cross-linked sodium carboxymethylcellulose for use as a superdisintegrant in pharmaceutical formulations for it’s dissolubility.

Magnesium Stearate

In this regard,magnesium stearate is useful because it has lubricating properties, preventing ingredients from sticking to manufacturing equipment during the compression of chemical powders into solid tablets; magnesium stearate is the most commonly used lubricant for tablets.
Author: Darlene Long
  1. Walaszek Z, Hanausek-Walaszek M, Adams AK, Sherman U. Cholesterol lowering effects of dietary D-Glucarate. FASEB 1991;5:A930.
  2. Walaszek Z, Hanausek-Walaszek M, Minton J, Webb TE. Dietary Glucarate as anti-promoter of 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis. Carcinogenesis 1986;7:1463-1466
  3. Walaszek, Z., E. Flores. And A. K. Adams. 1988 Effect of dietary glucarate on estrogen receptors and growth of 7,12 dimethylbenz(a)anthracene-induced rat mammary carcinomas. Breast Cancer Research and Treatment 12:128
  4. (J National Cancer Inst, 1989;81:1820-3 and Bio Chem Pharmacol, 1991;41 (10):1471-7)
  5. Walaszek, Z. 1993. Chemopreventive properties of D-Glucaric acid derivatives. Cancer Bulletin 45:453-7

Other References

  • Colborn, Theo. Our Stolen Future, New York: Dutton, 1996.
  • Curley, R.W., Jr., et al. (1994) Life Sciences 54(18): 1299-303.
  • Dwivedi, C. (1990) Biochemical Medicine & Metabolic Biology 43(2): 83-92.
  • Heerdt, A.S., et al. (1995) Israel Journal of Medical Sciences 31(2-3): 101-05.
  • Robbins, John. Reclaiming Our Health, Tiburon: HJ Kramer, 1996.
  • Walaszek, Z., et al. (1986) Carcinogenesis 7(9): 1463-6.