by Shop Talk Notes
Many people suffer daily from joint pain and discomfort caused from years of overuse or
from being overweight or obese. Joint pain and a loss of mobility can dramatically affect quality of life, making simple everyday activity difficult and painful. For years, people have turned to Herbs and supplements for relief of the devastating symptoms caused by aging and the loss of the freedom of painless mobility.
One of the hot topics in research is the subject of epigenetics. Epigenetics deals with the topic of how genes are expressed, rather than a true genetic malfunction based on a change to the DNA sequence. Researchers studying epigenetics now realize the power of environment and nutrition to influence gene function. What began as broad research focused on combining genetics and developmental biology by well-respected scientists including Conrad H. Waddington and Ernst Hadorn during the mid-twentieth century has evolved into the field we currently refer to as epigenetics. Epigenetics is the study of mechanisms that switch genes on or off. It is involved in every aspect of life and such reversible, inheritable changes affect the way we live as well as our future generations. The field of epigenetics is quickly growing and with it the understanding that both the environment and individual lifestyle can also directly interact with the genome to influence epigenetic change. These changes may be reflected at various stages throughout a person’s life and even in later generations. http://www.whatisepigenetics.com/fu…
Researchers now know, certain bio-active compounds can in fact change how our genes express themselves and interrupt the degenerative and inflammatory processes that cause so many of today’s health concerns and disease.
At Unicity we are bringing to market a ‘New Product Class’ called Genomeceutical. These products are filled with highly researched and potent nutrient formulations which have shown amazing benefits for many of the most devastating conditions today. Joint Mobility is one of these products.
The ingredients contained in Joint Mobility work in several different ways to help maintain overall joint health. Curcumin and Boswellia extract have been shown to down regulate the genes involved in chronic inflammation. Vitamin D3 has been shown to help increase collagen production which is needed to maintain overall joint health.
Joint Mobility works in several different ways for a multifaceted approach to joint health. The ingredients contained have been shown to inhibit proinflammatory pathways, and also help to prevent the breakdown of joint collagen allowing the body to repair and heal itself.1
Unicity Joint Mobility
Ingredients and more about the ongoing research.
Turmeric (Curcuma longa) has been used for 4,000 years to treat a variety of conditions. Studies show that turmeric may help fight infections and some cancers, reduce inflammation, and treat digestive problems.
Because of turmeric’s ability to reduce inflammation, researchers have wondered if it may help relieve osteoarthritis pain. At least 2 million Americans have definite or classical rheumatoid arthritis, a number that has been increasing in recent years. It is a much more devastating illness than previously appreciated. This is NOT the same condition as the far more common and generally less serious osteoarthritis or degenerative joint disease. The annual cost of this disease in the U.S. is estimated to be over $1 billion. A review of contemporary treatment methods shows that medical science has not been able to significantly improve the long-term outcome of this disease.
- An M.D. Anderson Cancer Center review of curcumin research, in the journal Phytotherapy Research in 2014, found that it regulates inflammation that “plays a major role in most chronic illnesses, including neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases.”
- Yet another M.D. Anderson study found that curcumin exhibits “antioxidant, anti-inflammatory, antiviral, antibacterial, antifungal, and anticancer activities,” all bolstering its “potential against various malignant diseases, diabetes, allergies, arthritis, Alzheimer’s disease and other chronic illnesses.”
In a small 2012 pilot study, a curcumin product called BCM-95 reduced joint pain and swelling in patients with active RA better than diclofenac, a nonsteroidal anti-inflammatory drug (NSAID).
There are no guarantees that turmeric or its active ingredient of curcumin will work for everyone. Researchers also caution that they may delay but not prevent, or slow down but not stop, a medical condition.
Boswellia (boswellia serrata) is a tree gum resin that has multiple health benefits. Also known as frankincense. In today’s alternative health world boswellia is widely regarded as a potent anti-inflammatory nutrient, wherein its primary active ingredient, acetyl-11-keto-β-boswellic acid (AKBA), inhibits the inflammatory enzyme 5-lipoxygenase. Excess 5-lipoxygenase is common in joint pain, allergies, respiratory conditions, and cardiovascular problems.
Studies show that boswellia may reduce inflammation and may be useful in treating:
- rheumatoid arthritis (RA)
- inflammatory bowel disease
- One study published in the journal Phytomedicine found that all 30 patients with OA knee pain who received boswellia reported a decrease in knee pain. They also reported an increase in how far they could walk and knee flexion.
- OA knee pain decreased after 90 days with the boswellia product. It also helped reduce the levels of cartilage-reducing enzyme.
- One study published in the Journal of Rheumatology found that boswellia might help to reduce RA joint swelling.
- Besides being an effective anti-inflammatory, boswellia can be an effective painkiller and may prevent the loss of cartilage. Some studies have found that it may even be useful in treating certain cancers, such as leukemia and breast cancer.
A number of new studies give insights into boswellia, a unique nutrient, even expanding its potential usefulness.
- A recent review of boswellia highlighted its many uses in traditional ayurvedic medicine: arthritis, diarrhea, dysentery, ringworm, boils, fevers (antipyretic), skin and blood diseases, cardiovascular diseases, mouth sores, bad throat, bronchitis, asthma, cough, vaginal discharges, hair loss, jaundice, hemorrhoids, syphilitic diseases, irregular menses and liver stimulation. In modern times boswellia has accumulated scientific data supporting its anti-arthritic and anti-inflammatory uses, along with the ability to lower cholesterol, prevent plaque buildup, and defend your liver.
- Boswellia in an animal experiment of intentionally induced free radical damage, reduced the amount of damage in the liver by 80 percent and in the heart by 50 percent. The researchers demonstrated potent anticoagulant properties, significantly reducing platelet aggregation and could be vital to healthy circulation and stroke prevention. (Note: Caution while taking anti-coagulants check with your doctor.)
- The Association of Joint Pain and Obesity shows a common finding. Researchers now know that it isn’t just the extra weight causing mechanical wear and tear. There appears to be common inflammation mechanisms causing both joint destruction and obesity. One emerging culprit is excessive amounts of lipopolysaccharide (LPS). LPS is generated as bacteria sheath off their outer wall. Overweight individuals typically have imbalanced digestive bacteria making larger-than-normal amounts of LPS, which enter general circulation and trigger inflammation, including joint inflammation. Another new study shows that boswellia can directly attach itself to toxic LPS, preventing the LPS from doing anything inflammatory. This is a novel way that boswellia reduces inflammation and is of particular value for individuals who are overweight and experiencing joint pain.
- We are now in an epidemic of type 2 diabetes. Interestingly, many people who persist in this condition also develop type 1 diabetes, because their pancreas gets too inflamed and tired out from having to try to make insulin all the time. A recent study shows that boswellia was able to prevent the rise in blood sugar due to toxin-induced type 1 diabetes. Boswellia protected the insulin producing cells in the pancreas from damage. It reduced a number of inflammatory messages, including two of the most common that are elevated when a person is overweight (IL-6 and TNFa). This study supports the idea that boswellia can help protect the pancreas.
Boswellia continues to be an exciting nutrient with multiple health benefits. There are many pathways of inflammation; boswellia is one of the most powerful natural inhibitors of the 5-lipoxygenase pathway. Since virtually every poor condition of health that sets in during aging is associated with increased amounts of inflammation, you need all the help you can get to tilt the balance of anti-inflammation in your favor.
Unhydrolyzed Collagen Type II
Hyaluronan (HA) is a long chain molecule that consists of alternating units of N-acetylglucosamine and glucuronic acid.2 Its molecular weight may range from 50,000 to 4 million Daltons. HA can absorb up to 3,000 times its weight in water and is an important hydrating agent for tissue.2 HA is found in virtually all tissues and fluids of the body, especially in synovial (joint) fluid, the eyes’ vitreous fluid and in skin.2 HA plays a critical role in maintaining healthy joint synovial fluid and preventing the degeneration of aging joints. HA has high daily turnover, so large amounts may be needed to maintain normal levels. HA is also a regulatory molecule influencing cell movement, phagocytosis and blood vessel formation.2 HA also serves as a free radical scavenger and antioxidant, and may be particularly important to protect the skin from the aging effects of excessive sunlight exposure.2 HA is critically involved in healthy wound healing.2 HA stimulates DNA synthesis and fibroblast cell division, essential for healthy skin and cartilage maintenance.3 By the time a person reaches age 30, his or her HA becomes disorganized from skin collagen protein, compared to the interweaving of HA and skin collagen in a nine-year-old, and is even more disconnected in the skin of 60-year-olds.4
Hyaluronan & Type II Collagen
Given the importance of HA for healthy skin and joints, its high turnover and “normal” decrease with aging, an effective, absorbable source of HA is highly desirable. Fortunately a bioavailable source of HA is now available: chicken sternum type II collagen.
- In February 2004 Dr. William Judy, senior scientist at SIBR Research, announced the results of a double blind clinical study with Collagen Type II™. In a 36-hour peak absorption study using a single dose, Collagen Type II, HA significantly increased in the blood at four hours after ingestion, and peaked at a level 7,000 percent above the placebo control’s levels in 12 hours. In a 28-day steady state bioavailability study using a constant daily dose, after seven days the Collagen Type II, HA levels became stabilized and remained so throughout the study at a level 3,543 percent higher than controls. Thus, regular use of Collagen Type II can be expected to provide a significant dose of HA to supplement the age-declining tissue levels of HA typical of most people.
Type II Collagen
- The benefits of type II collagen don’t stop with HA. Type II collagen, the collagen that makes up moveable joints, also provides a high level (typically 20 percent) of chondroitin sulfate (CS). CS is one of six glycosaminoglycans (GAG) that help form the connective tissue of skin, tendons, cartilage, ligaments and bone matrix. CS is an effective anti-inflammatory compound without the negative side effects of the non-steroidal anti-inflammatory drugs. CS also enhances the synthesis of HA and cartilage proteoglycans in osteoarthritis patients, improving the quality of their joint tissue.6
- Type II collagen also contains cartilage matrix glycoprotein (CMGP). CMGP enhances the antioxidant protection within joints by carrying the essential trace mineral copper to the chondrocytes.The chondrocytes produce new collagen and mucopolysaccharides to keep joints well cushioned and lubricated.
- The chondrocytes also produce and secrete copper SOD (superoxide dismutase), a free radical-destroying enzyme that is critical to protect joint tissue from the free radical damage that occurs as part of the process of joint degeneration.7
- Collagen II has multiple protective benefits; 1) resist cartilage protein digesting enzymes; 2) reprogram destructive chondrocytes to lessen inflammation; 3) promote new cartilage and proteoglycon synthesis; 4) enhance production of HA, producing a thick, effective, lubricating synovial fluid that protects and cushions joints; 5) protect the surface of cartilage from oxidative (free radical) damage and enzymatic digestion; and 6) act as powerful anti-inflammatory/pain modulators.7
- There have been a number of studies conducted with UC-II on both animals and humans, including research at the Harvard University Medical school — all of which have shown that the undenatured type II chicken collagen found in UC-II effectively reprograms the immune system to promote healthy joints and increase joint mobility and flexibility.
- In a pilot clinical study, for example, 5 older women (58-78 years old) suffering from significant joint pain were given undenatured type II chicken collagen (10 mg/day) for 42 days. Improvements in pain reduction and joint flexibility were reported, along with reduced morning stiffness
- In another study, researchers at Harvard Medical School found that six of ten rheumatoid arthritis patients taking undenatured type II collagen for three months showed substantial improvement, while one patient recovered completely. In addition, there were no side effects.
- In a 2009 randomized, double-blind, clinical study, 40 mg of UC-II was more than two-times as effective as 1,500 mg of glucosamine + 1,200 mg of chondroitin in supporting joint health, comfort, and flexibility.1 UC-II outperformed the glucosamine/chondroitin combination using three different assessment tools:
- And finally, in a 90-day, double-blind, placebo-controlled, follow-up study on patients with severe rheumatoid arthritis, Harvard scientists found that 28 patients taking undenatured type II collagen showed significant improvement compared to the placebo group, while four patients recovered completely.2
What It Means
For anyone suffering from progressive cartilage damage (which ultimately means anyone suffering from rheumatoid arthritis or long term osteoarthritis), reprogramming the immune system with Undenatured Type II Chicken Collagen as found in UC-II is an essential component of his or her joint repair regimen.
A growing number of researchers who have widely studied Vitamin D3 are almost begging the general public to consume more of this important nutrient.
References: 1. Sardi, B. Restoring youth with hyaluronic acid. Total Health for Longevity, 2002, 23(6). 2. Anderson, I. The properties of hyaluronan and its role in wound healing. Prof Nurse, 2001, 17:232-35. 3. Greco, R. et al. Hyaluronic acid stimulates human fibroblast proliferation within a collagen matrix. J Cell Physiol, 1998, 177:465-73. 4. Ghersetich, I. & Lotti, T. Hyaluronic acid in cutaneous intrinsic aging. Int J Dermatol, 1994, 33:119-22. 5. Champe, P. & Harvey, R. Lippincott’s Illustrated Reviews: Biochemistry. Philadelphia: J.B. Lippincott, 1994:147-55. 6. Ronca, F. et al. Anti-inflammatory activity of chondroitin sulfate. Osteoartritis & Cartilage, 1998, 6 (Suppl A):14-21. 7. Duarte, A. The Collagen Type II Cure for Arthritis and Heart Disease. 1997:39. 8. Oesser, S. & Seifert, J. Stimulation of type II collagen biosynthesis and secretion in bovine chondrocytes cultured with degraded collagen. Cell Tissue Res, 2003, 311:393-99. – 9. Novick, N. Tips for at-home anti-aging skin care. Total Health for Longevity, 2003, 25:44-46. Moskowitz, R. Role of collagen hydrolysate in bone and joint disease. Semin Arthritis Rheum, 2000, 30:87-99 http://www.wellnessresources.com/health/articles/curcumin_helps_change_gene_function_to_combat_cancer/ Vilai Kuptniratsaikul, Piyapat Dajpratham, Wirat Taechaarpornkul, Montana Buntragulpoontawee, Pranee Lukkanapichonchut, Chirawan Chootip, Jittima Saengsuwan, Kesthamrong Tantayakom, Supphalak Laongpech. Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study. Clin Interv Aging. 2014